Salinomycin is not expected to volatilize from dry soil surfaces based upon its estimated vapor pressure. Salinomycin was degraded 50-70% in soil in 7 day aerobic studies, 20-25% was attributed to abiotic reactions and the remaining portion was considered biodegradation. Salinomycin is a K+ ionophore antibiotic isolated from Streptomyces albus and known for more than 30 years. It has been used in veterinary medicine as an antimicrobial against Gram negative bacteria and coccidioides. Salinomycin is as an antimicrobial and anticoccidial antibiotic.

Salinomycin

The impact of salinomycin on patient-derived primary human colorectal cancer cells has not been investigated so far. Thus, here we aimed to investigate the activity of salinomycin against tumor initiating cells isolated from patients with colorectal cancer. Methods Primary tumor-initiating Salinomycin is an antibiotic isolated from Streptomyces albus that selectively kills cancer stem cells (CSCs). However, the antitumor mechanism of salinomycin is unclear. This study investigated the chemotherapeutic efficacy of salinomycin in human prostate cancer PC-3 cells. We found that cytotoxicity of salinomycin to PC-3 cells was stronger than to nonmalignant prostate cell RWPE-1 Salinomycin, a commercially significant coccidiostat isolated from , has been synthesised from three principal fragments. Key steps include (a) the use of η-allylmolybdenum cationic complexes 21a,b for the stereoselective construction of two contiguous stereogenic centres in fragment 5a; (b) the electrophilic cycli Salinomycin induces massive apoptosis in the multidrug-, radiation- and apoptosis-resistant human cancer cells.

16 May 2017 Salinomycin kills cancer stem cells by sequestering iron in lysosomes · Abstract. Cancer stem cells (CSCs) represent a subset of cells within 10 Dec 2018 Salinomycin is a monocarboxylic polyether ionophore that has been discovered in high throughput screening as a potential anti-cancer drug 11 Jun 2020 A high-throughput study in 2009 identified the potential of salinomycin to kill stem cell-like breast cancer cells and significantly reduce their tumor Treatment of 5 mg/kg salinomycin in mice implanted with SUM159 human breast cancer cells inhibits mammary tumor growth and induces increased epithelial Unfortunately Salinomycin sodium salt (Cat. No. 3637) has been withdrawn from sale for commercial reasons.

Salinomycin (Procoxacin) shows selective activity against human cancer stem cells. - Mechanism of Action & Protocol. Salinomycin sodium salt (Salinomycin sodium), an antibiotic potassium ionophore, is a potent inhibitor of Wnt/β-catenin signaling.

However, its biosynthesis had only been studied by feeding experiments with isotope-labeled precursors. A strategy with degenerate primers based on the polyether-specific epoxidase sequences was successfully developed to clone the salinomycin gene cluster. Using this Salinomycin is able to effectively eliminate CSCs and to induce partial clinical regression of heavily pretreated and therapy-resistant cancers. It has also been demonstrated as a positive ionotropic and chronotropic agent that increased cardiac output, left ventricular systolic pressure, heart rate, mean arterial pressure, coronary artery vasodilatation and blood flow, and plasma 2019-02-14 · Objectives Salinomycin is a polyether antibiotic with selective activity against human cancer stem cells. The impact of salinomycin on patient-derived primary human colorectal cancer cells has not been investigated so far. Thus, here we aimed to investigate the activity of salinomycin against tumor initiating cells isolated from patients with colorectal cancer. Methods Primary tumor-initiating Salinomycin is an antibiotic isolated from Streptomyces albus that selectively kills cancer stem cells (CSCs).

2.1 Pre-clinical. 3 Use in 4 Feb 2020 3.1 Salinomycin but not cisplatin attenuate cancer stem cell properties and promote apoptosis in colon CSCs. Several recent reports suggested Salinomycin sodium salt. Catalog # 3637. Datasheet / COA / SDS. Antibiotics Small Molecule. Discontinued Product. 3637 has been discontinued.
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Salinomycin Na+ ionophores are metabolized in the liver by cytochrome P450 enzymes, and are excreted mostly into bile and feces as parent compound and metabolites in poultry. Following oral administration, residues are present only at very low concentrations in liver and muscle that fall below the limit of decision of the assay within 2 days in poultry.

Salinomycin is an antibacterial and coccidiostat ionophore therapeutic drug. Contents. 1 Antibacterial activity; 2 Cancer research. 2.1 Pre-clinical.
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Salinomycin (SAL) is a veterinary antibiotic used to treat coccidiosis in chicken for more than 30 years (Naujokat et al., 2010). It came on the center stage in cancer drug studies after the revelation of its ability to specifically kill cancer stem cells (CSCs) (Gupta et al., 2009).

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Salinomycin is an ionophore, also marketed as a coccidiostat, which is related more closely to monensin than is lasalocid. The ionic affinity of salinomycin is predominantly to sodium and potassium ions, and its mode of action and cellular effects are similar to those of monensin.87. Salinomycin, traditionally used as an anti-coccidial drug, has recently been shown to possess anti-cancer and anti-cancer stem cell (CSC) effects, as well as activities to overcome multi-drug resistance based on studies using human cancer cell lines, xenograft mice, and in case reports involving cancer patients in pilot clinical trials. Salinomycin is as an antimicrobial and anticoccidial antibiotic. In 2009, a groundbreaking result was published in the scientific journal Cell (Ref), showing that Salinomycin can be effective in killing the cancer stem cells (CSC), the cancer cell population that is … Histopathologically, salinomycin induces severe myocardial and skeletal muscle lesions showing myocardial hyperemia, myocardial fiber degeneration and myocardial mitochondria damage.