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Drug and metabolite standards, Ecgonine methyl ester solution

It is a local anesthetic and vasoconstrictor and is clinically used for that purpose, particularly in the eye, ear, nose, and throat. Ecgonine methyl ester protects against cocaine lethality in mice. Hoffman RS(1), Kaplan JL, Hung OL, Goldfrank LR. A study of the metabolism of in vivo cocaine (COC) and the stability of in vitro COC suggests that the presence of benzoylecgonine (BE) in unpreserved blood arises from in vivo COC metabolism and that ecgonine methyl ester (EME) in unpreserved blood arises from in vitro COC hydrolysis. Ecgonine (tropane derivative) is a tropane alkaloid found naturally in coca leaves.

Ecgonine methyl ester

In humans, cocaine (COC) is extensively metabolized by both enzymatic and non-enzymatic pathways. Cocaine's primary metabolites include benzoylecgonine (BZE) and ecgonine methyl ester (EME) while norcocaine (NCOC), benzoylnorecgonine (BNE), m- and p-Hydroxycocaine (HOCOC) and m- and p-Hydroxybenzoylecgonine (HOBZE) are usually detected at considerably lower concentrations. O-hydroxy(phenyl)phosphinoyl ecgonine methyl ester (CHEBI:273574) has functional parent ecgonine methyl ester (CHEBI:31529) ecgoninium methyl ester(1+) (CHEBI:59908) is conjugate acid of ecgonine methyl ester (CHEBI:31529) Other names: (-)-Ecgonine methyl ester; Methyl 3-hydroxy-8-methyl-8-azabicyclo[3.2.1]octane-2-carboxylate; Ecgonine methyl ester Permanent link for this species. Use this link for bookmarking this species for future reference. Information on this page: Notes; Other data available: Gas Chromatography; Options: Switch to calorie-based units ECGONINE METHYL ESTER Y35FJB3QBJ Overview Structure Names 5: Identifiers 7: Relationships 2: Metabolites on Sun Feb 07 22:11:45 EST 2021 You are viewing an interactive 3D depiction of the molecule (-)-ecgonine methyl ester (C10H17NO3) from the PQR. Chemsrc provides ecgonine methyl ester(CAS#:7143-09-1) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of ecgonine methyl ester are included as well. Recently, ecgonine methyl ester (methylecgonine) has been shown to be major urinary metabolite of cocaine in man after oral administration.

Ecgonine methyl ester Ephedrine Epinephrine Gentisic acid. Guaiacol glycer ester Histamine Hydrochlorothiazide Homatrophine.

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Definition. Ecgonine methyl ester + NADP+ <=> Ecgonone methyl ester + NADPH + H+. Equation. C12448 + Ecgonine methyl ester is the O-debenzoyl analogue of cocaine. It has a role as a central nervous system depressant, a peripheral nervous system drug, Ecgonine methyl ester hydrochloride.

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The analytes were isolated from human plasma by subsequent solid-phase extraction and were separated o … Stability of ecgonine methyl ester in postmortem urine specimens. Levine B(1), Ramcharitar V, Smialek JE. Author information: (1)Office of the Chief Medical Examiner, State of Maryland, Baltimore, USA. The generation of anhydroecgonine methyl ester [9,10,1l], ecgonine methyl ester [11] and pseudoecgonine methyl ester [11] as analytical artifacts have all been previously documented. It should be This MassBank Record with Accession AU161803 contains the MS2 mass spectrum of 'Ecgonine-methyl-ester (EME)' with the InChIKey 'QIQNNBXHAYSQRY-ABIFROTESA-N'. This website uses technical necessary cookies (e.g.

Most other metabolites are pharmacologically inactive or have very low activity. Anhydroecgonine methyl ester (AEME) results from cocaine pyrolysis and can be used as a marker for crack cocaine use. Depending on the biological matrix examined, the amount of parent drug (cocaine) varies.
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Definition. Ecgonine methyl ester + NADP+ <=> Ecgonone methyl ester + NADPH + H+. Equation. C12448 + Ecgonine methyl ester is the O-debenzoyl analogue of cocaine.

→ Levorphanol. → Levomethorphan ester.
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Gabapentin, Gentamicin,. Haloperidol, Hydoromorphone av G Höst · 2007 · Citerat av 5 — Converting human carbonic anhydrase II into a benzoate ester hydrolase through cocaine, benzoylecgonine, and ecgonine methyl ester using electrospray. Levophenacyl-morphan. → Ecgonine. → Levorphanol. → Levomethorphan ester.